Serene by Nature Mare Calming Cream

(4 customer reviews)


Serene by Nature topical cream promotes mare calmness and focus.

  • One 6 oz tube lasts approximately 3 cycles, or 2-3 months.
  • Easy topical application.
  • Bio-identical, safe, natural, and effective.
  • Veterinarian tested, approved, and recommended.
  • USEF and FEI compliant.
  • No known negative side effects or drug interactions.
  • Safe alternative to synthetic drugs.
  • Includes Free Gloves for application.

Serene by Nature cream is a safe, effective, natural, and USEF and FEI compliant topical cream that helps support a healthy endocrine system for calmer and more focused mares (may be used on non-cycling equines as well).


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Serene by Nature topical cream

is specifically formulated to decrease irritability and improve attitude in nervous and cranky mares. Serene by Nature topical cream may be beneficial in dealing with the cyclical changes all mares experience. Reproductive health may be improved by supporting the endocrine system via a normal healthy balance.

Providing natural endocrine support may help to improve daily demeanor, focus, trainability, and overall well-being.

This product may be beneficial for:

  • Helping to maintain a calm and serene disposition on a daily basis.
  • Ease and regularity of seasonal cycles.
  • Supporting a healthy reproductive system.




Additional information

Weight 0.4375 lbs
Dimensions 7 × 2 × 2 in
Free Glove Size

Medium, Large

4 reviews for Serene by Nature Mare Calming Cream

  1. evelyngward

    I absolutely love Serene By Nature. Before I put my mare on it she would charge you, rear up on the lead, bite and kick. She was a nightmare to be around. I have had her on the cream since March of 2017 and she is a completely different horse. I started seeing results just 3 days into using Serene by Nature. I highly recommend this for anyone having difficulties with their horse.

  2. evelyngward

    5 stars for an amazing product!

  3. CookCathy (verified owner)

    I have been using Serene by Nature for about 1 1/2 years now. I was gifted a bottle from a friend, and was initially skeptical. (I have been a horse trainer for 30 years, to give you a little background). My mare was VERY spooky and reactive to noises outside the ring. In addition, lacking focus, especially when it comes to having a new gelding neighbor next to her (which has happened a few times, as I am a boarding facility, and I have no control of who moves in/out).

    I noticed a change in her almost immediately (few days). More calm, more relaxed, more focused, and the screaming stopped.

    My girl doesn’t have a mean bone in her body, she was just raised in a very quiet environment and had been out of work for some time. So, bringing her to a busy boarding facility was a huge change for her.

    Fast forward, to today, and I have posted a couple of testimonials before……she is doing AMAAAZING, and I even have a couple of students who ride her one day/week who absolutely LOVE HER.

    She is a very BIG BODIED Friesian and very powerful. She has lost that “edge” that is not very desirable. I am having a blast with her, and I am thrilled to be able to share her with her other riders.

    I ran out of Serene by Nature at one point, and I had to get something over the counter, so I tried “Mare Magic” which is simply raspberry leaves, also natural, but doesn’t have the same effect as Serene.

    It says one tube lasts 3 months, but mine lasted longer. I think I went through 2 tubes in a year. I wasn’t using much. With the 30 day money back guarantee, what have you got to lose? TRY IT.

    I know so many horses on Depo, or Regumate, which are hormones. Effective yes, but do you really want to give your horse a hormone? It is also VERY expensive.

    Try it. I would not recommend this product if I did not strongly believe in it.

  4. Taylor Willie (verified owner)

    I have only been using this for a short time and already I can tell a difference in my horses attitude. I will be recommending to all of my barn friends. Thanks for coming out with a safe natural product.

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